5.19: Locked In:
In a special episode of HOUSE, shot and told predominantly from the perspective of a patient, Mos Def guest-stars as Lee, a man who awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee and quickly annoys the doctors treating them both by insisting that Lee has “locked-in” syndrome. After House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to “unlock” him. Meanwhile, Wilson suspects House is hiding something when he refuses to divulge why he was in New York.

Another spoiler:
...the House ep is less about [Mos Def] and more about what's going on around him. "our doctors are told to keep his mind active," hints Shore, "and they wind up saying personal things they might not normally say."
Might House and Cuddy blab something that leads to their much-anticipated hookup? "I don't want to spoil the particulars," Shore hedges. "But I will confirm we are taking things forward [with them]."


5.20: Simple explaination
Charlotte (guest star Colleen Camp), an older woman who has spent the last six months taking care of her dying husband Eddie (guest star Meat Loaf), is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie begins to improve as Charlotte’s condition worsens. The previously unthinkable becomes real when it seems that Charlotte will die before Eddie, and the team will be forced to make a difficult decision.