House M.D. When did anda feel the worst for House?

Pick one:
When he had the infarction
When he sent Stacy away
When he was shot
When the ketamine treatment wore off and he started re-using his cane
When he was detoxing
When he told Eve his father abused him
When he had to attend his father's funeral
When he was in the bus accident (and the events that followed)
When Wilson left
When he found out Cuddy was adopting
Other (please elaborate)
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