Takumi Usui is one of the most popular boys at Seika High, Usui appears to take little interest in anything and prefers to observe things as they unfold, though proves to be extraordinarily talented in numerous areas. He develops an interest in Misaki and is the first to learn she is working at a maid café, but chooses to keep her secret and soon falls in Cinta with her. While she dismisses his behavior simply as harassment, he continues to watch over and protect her, as well as offering insightful Nasihat on how to deal with the boys at Seika effectively and fairly. He appears to be the only male student at school that Misaki is willing to speak to as an equal. Little is known about Usui’s background and he is reluctant to speak about it, though he reveals a willingness to tell Misaki. He has an older brother and lives alone in an apartment.

Misaki is the heroine of Kaichou wa Maid-sama!. She lives alone with her mother and her younger sister Suzuna, because her father abandoned them, leaving them with a huge debt. Because of her father's actions, she has a deep hatred for most boys (except the gentlemanly type).

She goes to Seika high school, which only recently became co-ed. It was an all-boy's school only a few years ago. Because of this, the student body is 80% male and 20% female. Misaki worked hard to become the student council president and "protect the girls." However, she has a secret. To help her mother pay off her father's debt, she has a part-time job... at a maid cafe! She doesn't want anyone at school to discover her, because she thinks that if they do, she will lose her authority as student council president.