Yes as the ending could of been better and they left several hints for another season within the last episode of soul eater like medusa's snake and Asura's mention of if hes killed there will always be another kishin to take his place.
Of course!! Soul eater is the definition of epicness!! I've seen way to many pics of season two to be coincidental so I think there is!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!