Meanwhile House and the team attend a wedding, Wilson's relationship with Sam unexpectedly changes, and Taub soalan his wife's relationship with a member of her infidelity support group.
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A girl is admitted to the hospital with smallpox, and the CDC institutes a lockdown. The doctor in charge forbids House's team from diagnosing, but Masters believes he has an ulterior motive.
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When a campaign manager falls ill with liver failure and temporary paralysis in the midst of an election race, the team must look to the manager's candidate and his surprising announcement in order to solve the case.
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